MicrobesOnline Comparative Genomics Database
The MicrobesOnline genome database contains over 1000 prokaryotic genomes.
All genomes are analyzed through the VIMSS genome pipeline. We use publicly available sequence analysis tools and databases to search for homologs (NCBI BLAST, UCSC Blat, SwissProt, COG) and protein domains (FastHMM, InterPro), to assign gene ontologies (Gene Ontology Consortium) and EC numbers and to map the metabolic pathways (KEGG). We then link the orthology relationships between genes, and predict operon structures and regulon networks.
Most genome data is downloaded from RefSeq. When an incomplete genome is directly downloaded from a sequencing center, we predict protein coding genes using CRITICA and Glimmer3, tRNA genes using tRNAscan, and other RNA genes by BLASTn. For all genomes, we search for CRISPR regions using PILER-CR and CRT.
All of the information in the VIMSS genome database is freely available on our website.
We update our analyses with the latest release of each database every six-twelve months.
last updated July 2010MicrobesOnline Home Page